Localization of decay accelerating factor in normal and diseased kidneys
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چکیده
منابع مشابه
76 Decay - Accelerating Factor in Normal and Pnh
Decay-accelerat ing factor (DAF), 1 which is an inhibi tor o f c o m p l e m e n t and is present on e ry th rocy te membranes , was first descr ibed by H o f f m a n n (1, 2) and later isolated and character ized as an Mr 70,000 prote in by Nicholson-Weller et al. (3). DAF very effectively prevents the amplif ication steps o f the cascade by in ter fer ing with assembly o f the C3-convertases,...
متن کامل76 Decay - Accelerating Factor in Normal and Pnh Blood
Decay-accelerat ing factor (DAF), 1 which is an inhibi tor o f c o m p l e m e n t and is present on e ry th rocy te membranes , was first descr ibed by H o f f m a n n (1, 2) and later isolated and character ized as an Mr 70,000 prote in by Nicholson-Weller et al. (3). DAF very effectively prevents the amplif ication steps o f the cascade by in ter fer ing with assembly o f the C3-convertases,...
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Pericytes are interstitial mesenchymal cells found in many major organs. In the kidney, microvascular pericytes are defined anatomically as extensively branched, collagen-producing cells in close contact with endothelial cells. Although many molecular markers have been proposed, none of them can identify the pericytes with satisfactory specificity or sensitivity. The roles of microvascular peri...
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Decay-accelerating factor (DAF) ~ is a membrane protein that inhibits amplification of the complement cascade on cell surfaces. By binding to C3b or C4b complement fragments that accidentally deposit on the cell membrane, DAF blocks the assembly of both the classical and alternative C3 and C5 convertases (1-3). In this manner, DAF protects host cells from damage by autologous complement. DAF is...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1989
ISSN: 0085-2538
DOI: 10.1038/ki.1989.167